MeiSaku

MeiSaku is the femslash ship between Sakuya Izayoi and Hong Meiling in the Touhou series.

Canon
They are fellow employees in the Scarlet Devil Mansion and both are implied to be in a friendly, if somewhat formal, relationship between the two of them. Meiling constantly pesters about Sakuya's work productivity. Meiling seems easily frightened when Sakuya shows even a slight bit of anger as shown in Strange and Bright Nature Deity.

Sakuya is also shown to care for Meiling, though is strict about her not slacking off. In Meiling's Touhou Hisoutensoku ending, when Meiling is found sleeping on the job, Sakuya takes Meiling inside because she is worried Meiling will get heatstroke.

Fanon
Usually involves Meiling having an unrequited crush on Sakuya and Sakuya frequently stabbing Meiling in the head for not doing her job as door guard. However, the violent factor of this relationship has become less prevalent lately, especially with some fanart depicting a younger Sakuya looking up to Meiling like an older sister.