Toxicandy

Toxicandy is a femslash ship between Seiko Kimura and Ruruka Andou in the Danganronpa series.

Canon
Ruruka is Seiko's childhood friend and fellow member of Class 76th. Ruruka always relied on Seiko to do jobs for her, something that led Seiko to mistakenly believe Ruruka was taking advantage of her. Ruruka also wanted Seiko to eat her sweets, but Seiko was unable to eat them, which made Ruruka very upset. Despite that, the two considered each other as close friends.

In the Danganronpa 3 manga, Seiko tried to eat one of Ruruka's sweets, which caused her to get infected and allergic to the point of almost dying. Ruruka then always went to visit Seiko while she was in the hospital and felt better.

Seiko, Ruruka, and Sonosuke all later attended Hope's Peak and unknowingly got involved in a school bombing because of Nagito Komaeda. Because of the misunderstanding, Ruruka thought Seiko intentionally gave her a wrong drug, causing her exams to fail. Seiko in turn was hurt by Ruruka's words and they both lashed out and let out the pent up anger they had felt towards each other for years. In addition, they were all expelled because of the bomb incident. These events led Seiko and Ruruka to hate and distrust one another, each believing the other to be a traitor.

However, the two have shown to be regretful of what happened in their past. While Seiko engages Ruruka and Sonosuke in a fight-to-the-death battle, Seiko remembers wanting Ruruka to be her friend and wonders when everything went wrong. Seiko did not know that Ruruka felt the same way, and was not using her, but just felt glad to have someone she could depend on.

In the manga, it was seen that Seiko and Ruruka were talking to each other about her past and fixed what they did. Seiko also asked Ruruka for one of her sweets because she wanted to eat one before she dies in the killing game. In her final moments before being brainwashed into committing suicide, Seiko hears Ruruka's voice telling her that she just wanted to be her friend.

A drawing from Lerche's Twitter shows Ruruka attempting to feed Seiko her treats in the afterlife, with Seiko appearing very unwilling and uncomfortable, especially since Sonosuke is threatening her with a knife.