PicNene

PicNene is the het ship between Pico and Nene from the Pico's School fandom.

Canon
Pico and Nene are close friends since their high school days, having survived a school shooting and many other dangers together.

In Pico's School
Despite being confirmed to be friends, Pico and Nene's interactions in the original 1999 Flash game are unpleasant; being extremely overwhelmed and traumatized by the blood and violence of the school shooting, Nene begs Pico to shoot her and put her out of her misery. By the player's choice, Pico has the option to kill her or spare her. Canonically, however, she ends up surviving the massacre.

In Pico's School: Love Conquers All
In the April Fool's Day re-telling of the original Pico's School, due to there being no school shooting, Nene is happily walking down the hallway when she encounters Pico. The two have a brief, but pleasant conversation.

In Resident Pico
In Resident Pico, Nene warns Pico about the incoming zombies. Pico insists that he will protect Nene, but Nene refuses, expressing that she "can't wait to get [her] brains eaten" before running off.

In Friday Night Funkin'
While Friday Night Funkin' is more of a semi-canon offshoot to the Pico franchise instead of a direct continuation, in the upcoming update Nene is Pico's adversary who is trying to kill him. Despite how she wants him dead, PhantomArcade has stated that Pico turns her on, resulting in a strange mix of feelings towards him.

Fanon
Pico and Nene may have never had any romantic interactions in the official Pico series, but due to Nene being the token girl in Pico's friend group and Pico being the protagonist, Pico and Nene were frequently shipped together in early Newgrounds fanworks (notable examples being Pico in Time and Pico vs. Convict). As a result, it is the most popular Pico's School ship as well as being a common ship in the Friday Night Funkin' fandom. It is the most popular ship for Nene and the second most popular ship for Pico (surpassed only by Pico x BF).

Interpretations of the ship vary between the two fandoms. In the Pico's School fandom Pico and Nene are often portrayed as having a childhood friend romance, while Friday Night Funkin' fans depict their relationship as less emotional and more physical - they may be exes or friends-turned-rivals or friends-with-benefits. This stems from Nene's role in the upcoming FNF update as an opponent, seen in the trailer for said update chasing Pico and throwing knives at him with a malicious grin.

PicNene's biggest rival ship is Picandra, with Nene and Cassandra often depicted as rivals competing for Pico's love. Many Pico's School fans also ship Nene x Cassandra, however. Another rival ship is Darnene (Darnell x Nene), though it is less popular.

Fandom
TWITTER