Komamiki

Komamiki is a het ship between Nagito Komaeda and Mikan Tsumiki in the Danganronpa series.

Canon
''' WARNING: This section contains heavy spoilers for Danganronpa 2. '''

At first, Nagito worries about Mikan, as he scolds Hajime after thinking he bullied her and asks if she's okay after having one of her many exaggerated falls. He is also very humbled during the first trial, when he mistakenly assumed that Mikan complimented his appearance when she pointed out that there wasn't any blood on him.

After Nagito caught the Despair Disease, Mikan took care of him along with the others. However, she also caught the disease, and despite his terrible condition, he noticed that she had fallen into despair. Because of this, and the murders she committed for the sake of despair, Nagito lost all respect for her and considered her an enemy, worthy of the name "Ultimate Despair". Unlike the others, he wasn't fooled by her act during the trial and he bitterly refused to forgive her.

However, Mikan told Nagito that he's wrong and claimed that she had killed for "her beloved". Somewhat mockingly, she said that Nagito doesn't understand because he doesn't have anyone to love and isn't accepted by anyone, leaving him at a loss for words.

Later though, after Nagito and Mikan awaken from their comatose state, he doesn't seem to hold anymore hatred towards her. This probably means that Nagito's original relationship with Mikan, which was mostly him not paying attention to her, although thinking her talent is amazing, has returned.