Despair Sisters

Despair Sisters is the family/femslash ship between Junko Enoshima and Mukuro Ikusaba from the Danganronpa fandom.

Canon
THEY'RE SISTERS - NO THIS IS NOT CANON.

Fanon
The familyship sailed as a result of the two canonically being sisters. It received mixed feedback from the fans. While some find it heartwarming how both sisters care for each other in their own unique way, even if it includes Junko trying (and later succeeding) to kill Mukuro because she knows she'd feel a huge despair if she killed her own sister; the others are appalled by it for the same reasons.

Since later installements appear to hint an incestous attraction to Junko on Mukuro's part, the ship caused another controversy. Most of the fans preferred it as just a familyship than a femslash one. As such, it only ended up losing in popularity, although that was the case since the very beginning, as many considered the sisters' relationship to be toxic from the get-go.

Regardless of whether one ship it as a family or a femslash ship, both sides usually don't enjoy the abuse Mukuro suffers at Junko's hands. They also aren't in favor of Mukuro being portrayed in Danganronpa 3 and Killer Killer as a Despair Mikan 2.0 and a right-hand to her sister. Such fans were glad when she finally stood up for herself in the alternate universe of Danganronpa: IF.