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TOS= In the 23rd Century, the Spaceship U.S.S. Enterprise is on the Five-Year-Mission to explore the unchartered parts of the Milky Way Galaxy. The (mostly) human Crew consist of Captain James T. Kirk, his first officer, the half-Human half-Vulcan Science Officer Commander Spock, Chief Medical Officer Dr. Leonard McCoy, Scottish Chief Engineer Lt. Cmdr. Montgomery Scott, Japanese-American helmsman Lt. Hikaru Sulu, East African Communications Officer Lt. (Nyota) Uhura and Russian navigator Ensign Pavel Andreievich Chekov. Recurring Characters include Yeoman Janice Rand and Nurse Dr. Christine Chapel. The continuation of the voyages of the USS Enterprise, previously featured in the original Star Trek series. The series involves a starship named Enterprise and is set in the nearby regions of the Milky Way galaxy, the Alpha Quadrant. The first episode takes place in the year 2364, 100 years after the start of the five-year mission described in the original series, which began in 2264. It features a new cast and a new starship Enterprise, the fifth to bear the name within the franchise's storyline. DS9 centers on the formerly Cardassian space station Terok Nor. After the Bajorans have liberated themselves from the long and brutal Cardassian Occupation, the United Federation of Planets is invited by the Bajoran Provisional Government to administer joint control of the station, which initially orbits Bajor. The station is renamed Deep Space Nine, and a Starfleet crew is assigned to manage it. Shortly after their arrival, the Starfleet crew discovers a stable wormhole in Bajoran space leading from the Alpha Quadrant to the Gamma Quadrant, and the station is moved to a strategic position near the wormhole's entrance to safeguard it from the Cardassians. Deep Space Nine and Bajor quickly become a center for exploration, interstellar trade, political maneuvering, and open conflict. Threats come not only from Cardassians, Klingons, and Romulans from the Alpha Quadrant, but later from the Dominion, an alliance of alien species from the Gamma Quadrant that take up arms alongside the Cardassians against the Federation and its allies starting in Season 3. Deep Space Nine becomes a key military base for the Federation in the Dominion War, and is assigned the starship USS Defiant to aid in its protection. Launched in the year 2371, the Intrepid-class Federation starship USS Voyager was a ship built to return to Starfleet's founding principle of scientific exploration. It was fitting that the ship's captain, Kathryn Janeway, rose up through the science ranks rather than command. On the ship's first mission while departing the space station Deep Space 9, which required it to find and capture a Maquis vessel that disappeared into the treacherous Badlands, the crews of both Voyager, as well as the Maquis ship it was pursuing, were swept clear across the galaxy and deep into the Delta Quadrant. This was the doing of a powerful alien being known as the Caretaker. The 70,000 light year transit cost the lives of over a dozen crew members. Captain Janeway was forced to destroy the massive alien array that housed the remains of the Caretaker. In doing so, she saved an alien race, the Ocampa, but stranded Voyager and the crew in the Delta Quadrant.
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United in a common purpose, the surviving Maquis rebels joined with Janeway's Starfleet-trained crew on Voyager. Though a journey back to the Alpha Quadrant would have taken more than seventy years through unknown and treacherous territory, the crew of Voyager was well served by Janeway's skilled leadership and their own steadfast determination. Ultimately, Voyager returned to the Alpha Quadrant in seven years. Star Trek: Enterprise follows the adventures of the crew of the starship Enterprise, designation NX-01. They are the first deep space explorers in Starfleet, using the first Warp 5 equipped vessel. At the start of the series, it is revealed that the Vulcans have withheld advanced technology from humanity since their first contact, concerned that humans were not ready for it. This has delayed human space exploration and caused resentment in Captain Jonathan Archer, whose father developed the Warp 5 engine but did not live to see it used.
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Enterprise was intentionally equipped with less advanced versions of technologies seen in previous series. For example, it has no tractor beam, uses missiles instead of photon torpedoes, and has only limited means of synthesizing foods and other consumable items. Communications Officer Linguist Hoshi Sato's expertise in linguistics helps compensate for the lack of advanced universal translators.

The series also showed the crew making first contacts with a number of races previously seen in the franchise. Notably, the Klingons who appear in the pilot, "Broken Bow" have the ridged makeup seen in the movie franchise and from Star Trek: The Next Generation onwards, rather than the smooth-headed versions seen in Star Trek: The Original Series. This particular change was attributed by Berman and Braga to advancements in makeup. They felt that contradictions in the continuity such as the Klingon ridges were unavoidable, as well as those involving technology.
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Set roughly ten years before the events of Star Trek: The Original Series, the show sees the united Klingon houses in a war with the United Federation of Planets that involves the crew of the USS Discovery.
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