Twomiki

Twobuki is a het ship between Ultimate Imposter and Mikan Tsumiki in the Danganronpa series.

Canon
Although the two have little to no interaction in Danganronpa 2, their relationship gets to be developed more in Danganronpa 3: Despair Arc.

In episode 5, after noticing Ryota Mitarai works so hard on his anime that he began neglecting his health, Ultimate Imposter forcibly takes Mikan Tsumiki and brings her to Ryota's room, knowing that thanks to her status as the Ultimate Nurse she'll be able to nurse him back to health and trusting her with his and Ryota's secret. She assumes that the Ultimate Imposter will either want to kill her or want sex in exchange for knowing too much, but the Imposter quickly assures her that he trusts his classmates. Mikan begins to cry, saying no one has been this nice to her yet. As a response, Imposter tells her to have more confidence.

In episode 7, Imposter goes away with Mikan and pins her against the wall in a kabe-don fashion, in order to tell her about Ryota Mitarai's disappearance. Mikan promises to look for him, which eventually leads her to meet Junko Enoshima and Mukuro Ikusaba. Meanwhile, the classmates start wondering where the two could have gone, with Kazuichi Souda and Teruteru Hanamura having some suggestive ideas, which the later shows with an example of a donut and a banana.

In episode 8, after Mikan skips classes again, when Nagito Komaeda reveals he had seen her going to the west district, Ultimate Imposter reacts very aggresively, asking him if he's sure about that. Nagito himself points out he doesn't remember Imposter as this type of character. Ultimate Imposter looks for Mikan along with the rest of the classmates. He is seen to be very worried about her, to the point of not being hungry, unlike usual.