SteMedu

SteMedu is the het ship between Franken Stein and Medusa Gorgon from the Soul Eater fandom.

Canon
Stein and Medusa meet for the first time when he and Spirit come to the aid of Maka and Soul and fight Crona. After Stein and Spirit defeat Crona, Medusa dissolves her soul protection and makes herself noticeable. When Stein senses her soul, he describes her as a very powerful witch. Medusa attacks them, but Stein fends it off with his witch hunt. She complements their counter attack and retreats with Crona.

Even before the plot began, Medusa had managed to get herself arranged as the school nurse for the DWMA, but Stein suspected that she was a witch and investigated. Stein confronts Medusa about the medicine she gave Maka. She replies that the medicine is used to stimulate blood circulation. Shortly afterwards, Stein asks her if she is a witch, whereupon Medusa accuses him of sexual harassment. Stein laughs and says that if she wants to sue him, she should sue Spirit first. After this confrontation, Stein feels fear again for the first time in a long time, for which he thanks Medusa.

During the party celebrating the anniversary of the founding of the academy, Stein pretends to be drunk to get Medusa to dance with him. Medusa is confused by his behavior because she can't tell whether he's just acting drunk or not, and she doesn't want to be seen that way by her subordinates. As they dance, Stein confronts her with her plan. Medusa reveals her motivation and suggests that Stein join her. For a moment it seems as if her offer will be taken up and the two are about to kiss, but they are interrupted by the arrival of Sid.

Below the academy, Stein fights Medusa with Spirit. As the fight progresses, Medusa offers Stein to join her, which he declines. Eventually, Stein manages to defeat Medusa when she is distracted by the Kishin's resurrection. Even after she is defeated and split in two, Medusa clings to Stone and says that she loves him. Stein replies that they both cannot love and gives her the death blow. What he doesn't know, however, is that Medusa survived by implanting her soul into a snake.

After the battle beneath the academy, Stein has hallucinations of Medusa continuing to tempt him into giving in to madness. Medusa manipulates Crona into making Marie consume a liquid that allows them to spy on Marie and Stein and drive Stein further mad.

Anime
In the anime, Medusa manages to drive Stein further mad, so that he eventually leaves the DWMA and joins them. He fights with her against Marie and Crona, who try to bring him back and defeat Medusa. After they manage to bring Stein back to his senses with the help of Maka and Soul, he fights with Marie against Medusa. Finally, Maka drives Medusa out of Rachel's body and finally defeats her, while Stein returns to the DWMA with the others.

Fanon
SteMedu is a ship with moderate popularity in the Soul Eater fandom. There are currently over 60 works on AO3. SteMedu is Medusa's most popular ship and Stein's 3rd most popular ship. Fans ship these two together because there was a clear attraction between the two. Fans like the idea of the two of them become a mad scientist power couple.

Fandom

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Variations
SteMariMedu — the ship between Stein, Marie Mjolnir and Medusa